As the processing of large-scale graphs on a single device is infeasible without partitioning, graph partitioning algorithms are essential for various algorithms and distributed computing tasks utilizing graph data.However, graph partitioning is a nondeterministic polynomial time NP-Complete problem, which is characterized by high computational com
The chirality quantification is of great importance in structural biology, where the differences in proteins twisting can provide essentially different physiological effects.However, this aspect of the chirality is still poorly studied for helix-like supramolecular structures.In this off white 5000 puffs work, a method for chirality quantification
ObjectiveCyclin-dependent kinase 1 (CDK1)/cyclin B1 phosphorylates many of the same substrates as mTORC1 (a key regulator of glucose metabolism), including the eukaryotic initiation factor 4E-binding protein 1 (4E-BP1).Only mitotic CDK1 phosphorylates 4E-BP1 at residue S82 in mice (S83 in humans), in addition to the common 4E-BP1 phospho-acceptor s
A variety of circumstantial evidence from humans has implicated the B cell antigen receptor (BCR) in the genesis of B cell lymphomas.We generated mouse models designed to test this possibility directly, and we found that both the constitutive and antigen-stimulated state of a clonal BCR affected the rate and outcome of lymphomagenesis initiated by
IntroductionThe spread of antimicrobial resistance (AMR) is a major threat to human and animal health.Therefore, new solutions are needed to prevent returning to a world without effective antibiotics.Mastitis in dairy cows is a major reason for antimicrobial use in food animal production, and mastitis-causing bacteria have the potential to develop